LOM612 | FOXO1 activator | Probechem Biochemicals

Chemical Structure : LOM612

CAS No.: 2173232-79-4

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LOM612 (LOM 612, LOM-612)

货号: PC-21525Not For Human Use, Lab Use Only.

LOM612 is a potent FOXO relocator and activator, potently activates nuclear translocation of FOXO with EC50 of 1.5 uM in cell-based FOXO reporter assays.

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5 mg	￥2880	In stock
10 mg	￥4780	In stock
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生物&药学活性

LOM612 is a potent FOXO relocator and activator, potently activates nuclear translocation of FOXO with EC50 of 1.5 uM in cell-based FOXO reporter assays.
LOM612 potently induces FOXO translocation in a dose-dependent manner.
LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor.
LOM612 efficiently induces translocation of endogenous FOXO3a and FOXO1, increases FOXO target genes p27 and FasL in U2OS cells.
LOM612 compromises the viability of human cancer cell lines(HepG2 cells, IC50=0.64 uM).

物理化学性质&存储条件

分子量	258.30
分子式	C13H10N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(Dimethylamino)naphth[2,3-d]isothiazole-4,9-dione

参考文献

1. Bastien Cautain, et al. PLoS One. 2016 Dec 9;11(12):e0167491.

LOM612 (LOM 612, LOM-612)

生物&药学活性

物理化学性质&存储条件

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LOM612 (LOM 612, LOM-612)

生物&药学活性

物理化学性质&存储条件

参考文献

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