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首页-小分子抑制剂&激动剂-Apoptosis-Ferroptosis-LOC1886
LOC1886

Chemical Structure : LOC1886

CAS No.: 951948-38-2

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LOC1886 (LOC-1886)

货号: PC-49542Not For Human Use, Lab Use Only.

LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4.

    物理化学性质&存储条件

    分子量 241.250
    分子式 C13H11N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1H-imidazol-1-yl)(4-methoxy-1H-indol-2-yl)methanone

    参考文献

    1. Liu H, et al. Cell Chem Biol. 2022 Dec 15;29(12):1680-1693.e9.

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