LOC14 | PDI inhibitor | Probechem Biochemicals

Chemical Structure : LOC14

CAS No.: 877963-94-5

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LOC14 (PDI inhibitor LOC14)

货号: PC-70321Not For Human Use, Lab Use Only.

LOC14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM.

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10 mg	￥1380	In stock
25 mg	￥2380	In stock
50 mg	￥3880	In stock
100 mg		Get quote

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生物&药学活性

LOC14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM.
LOC14-induced oxidation of PDI has a neuroprotective effect not only in cell culture, but also in corticostriatal brain slice cultures.
LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding.

物理化学性质&存储条件

分子量	317.41
分子式	C16H19N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one

参考文献

1. Kaplan A, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52.

2. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50.

LOC14 (PDI inhibitor LOC14)

生物&药学活性

物理化学性质&存储条件

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LOC14 (PDI inhibitor LOC14)

生物&药学活性

物理化学性质&存储条件

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