LNS8801

Chemical Structure : LNS8801

CAS No.: 925419-55-2

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货号: PC-23782Not For Human Use, Lab Use Only.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

LNS8801 is a specific, orally available small molecule agonist of G protein–coupled estrogen receptor-1 (GPER), induces both GPER-dependent and GPER-independent effects and elicits potent anticancer activities in vitro and in vivo.
LNS8801 induces differentiation markers and inhibits uveal melanoma cell proliferation and migration.
LNS8801 induces the formation of defective mitotic spindles and an arrest of the cell cycle in G2–M.
LNS8801 has potent antitumor effects in uveal melanoma xenograft.

物理化学性质&存储条件

分子量	412.28
分子式	C21H18BrNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((3aR,4S,9bS)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)ethan-1-one

参考文献

1. Ambrosini G, Natale CA, et al. Cancer Res Commun. 2023 Apr 5;3(4):540-547.

2. Lee I, et al. Cancer Res Commun. 2023 Aug 18;3(8):1594-1606.

LNS8801

生物&药学活性

物理化学性质&存储条件

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LNS8801

生物&药学活性

物理化学性质&存储条件

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