LNP509 | I1R agonist | Probechem Biochemicals

Chemical Structure : LNP509

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LNP509 (LNP-509)

货号: PC-23248Not For Human Use, Lab Use Only.

LNP509 is a potent, selective peripherally acting I1 imidazoline receptor (I1R) agonist with Ki of 537 nM, improves glucose tolerance and insulin sensitivity.

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生物&药学活性

LNP509 is a potent, selective peripherally acting I1 imidazoline receptor (I1R) agonist with Ki of 537 nM, improves glucose tolerance and insulin sensitivity.
LNP509 reduced the area under the curve of the intravenous glucose tolerance test and enhanced insulin hypoglycemic action and intracellular signaling (Akt phosphorylation).
LNP509 stimulated adiponectin secretion acting at I1R on adipocytes, resulting in increased plasma levels of adiponectin.
LNP509 also enhanced AMPK phosphorylation in hepatic tissues.

物理化学性质&存储条件

分子量	206.33
分子式	C13H22N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(dicyclopropylmethyl)-2,3-dimethyl-3,4-dihydro-2H-pyrrol-5-amine

参考文献

1. Weiss M, et al. Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E95-104.

2. Bousquet P, et al. Ann N Y Acad Sci. 2003 Dec;1009:228-33.

LNP509 (LNP-509)

生物&药学活性

物理化学性质&存储条件

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LNP509 (LNP-509)

生物&药学活性

物理化学性质&存储条件

参考文献

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