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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-LN5972
LN5972

Chemical Structure : LN5972

CAS No.: 3035425-93-2

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LN5972 (LN-5972)

货号: PC-22931Not For Human Use, Lab Use Only.

LN5972 (LN-5972) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LN5972 (LN-5972) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.4 uM.
LN5972 effectively reduced P-selectin expression by up to 97% in a platelet degranulation assay, showed potential for the treatment of platelet-mediated thrombosis.

物理化学性质&存储条件

分子量 422.55
分子式 C19H30N6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-Butyl 4-(3-((7-Ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino)propyl)ppiperazine-1-carboxylate

参考文献

1. Alp Bayrak, et al. J Med Chem. 2022 Oct 13;65(19):13365-13384.

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