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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-LN-439A
LN-439A

Chemical Structure : LN-439A

CAS No.: 2991822-04-7

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LN-439A

货号: PC-23140Not For Human Use, Lab Use Only.

LN-439A is a small molecule BRCA1-associated protein 1 (BAP1) inhibitor by binding to the catalytic pocket of BAP1, leading to the ubiquitination and degradation of Krüppel-like factor 5 (KLF5), inhibits proliferation and migration of BLBC cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LN-439A is a small molecule BRCA1-associated protein 1 (BAP1) inhibitor by binding to the catalytic pocket of BAP1, leading to the ubiquitination and degradation of Krüppel-like factor 5 (KLF5), inhibits proliferation and migration of BLBC cells.

物理化学性质&存储条件

分子量 439.49
分子式 C24H26FN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-(2-fluorophenyl)acetyl)-N-(2-(2-hydroxyethoxy)ethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-8-carboxamide

参考文献

1. Wang TT, et al. Acta Pharmacol Sin. 2024 Oct 8. doi: 10.1038/s41401-024-01361-1.

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