LMTK3 inibitor C28

Chemical Structure : LMTK3 inibitor C28

CAS No.: 2764850-23-7

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货号: PC-38206Not For Human Use, Lab Use Only.

LMTK3 inibitor C28 is a potent, ATP-competitive small-molecule inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 67 nM.

规格	价格	库存
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

LMTK3 inibitor C28 is a potent, ATP-competitive small-molecule inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 67 nM.
LMTK3 inibitor C28 displays high selectivity for LMTK3, only 18 of 140 kinases was reduced >50% in the presence of 1 μM, 4 kinases (CLK, 5 nM; DYRK1α, 6 nM; HIPK2, 48 nM; and IRAK4, 41 nM) have IC50 values of <50 nM.
LMTK3 inibitor C28 promotes proteasome-mediated degradation of LMTK3, an HSP90 client protein.
LMTK3 inibitor C28 exhibits potent anticancer activity in different human cancer cell lines (BC cells IC50=6.5-8.4 uM).
LMTK3 inibitor C28 inhibits tumor growth in orthotopic and transgenic mouse models of BC.

物理化学性质&存储条件

分子量	356.308
分子式	C18H11F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine

参考文献

1. Angeliki Ditsiou, et al. Sci Adv. 2020 Nov 13;6(46):eabc3099.

2. Chiara Cilibrasi, et al. Mol Cancer. 2021 Mar 17;20(1):53.