LMTK3 inhibitor C36

Chemical Structure : LMTK3 inhibitor C36

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货号: PC-49503Not For Human Use, Lab Use Only.

LMTK3 inhibitor C36 is a highly selective, ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 100 nM in in vitro kinase assays and MST binding Kd of 1.87 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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LMTK3 inhibitor C36 is a highly selective, ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 100 nM in in vitro kinase assays and MST binding Kd of 1.87 uM.
LMTK3 inhibitor C36 has a higher selectivity to purified human kinases when compared to C28 (Catalog#PC-38206).
LMTK3 inhibitor C36 interacts with the ATP-binding site of LMTK3 and with the substrate as well.
LMTK3 inhibitor C36 inhibits the growth of MCF7, T47D, and MDA-MB-231 BC cells, with IC50 values ranging from 16.19 µM to 18.38 µM.
LMTK3 inhibitor C36 (10 uM) inhibited all cancer cell lines by >40% against a panel of 60 human cancer cell lines.
LMTK3 inhibitor C36 (20 uM, 96 h) exhibited an apoptotic effect at 20 μM in MCF7 and T47D BC cell lines, respectively.

物理化学性质&存储条件

分子量	341.82
分子式	C16H12ClN5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-chlorophenyl)-N-(pyridin-3-ylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine

参考文献

1. Alessandro Agnarelli, et al. Int J Mol Sci. 2023 Jan 3;24(1):865.