LMT328 (LMT-328)

Chemical Structure : LMT328

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货号: PC-26684Not For Human Use, Lab Use Only.

LMT328 (LMT-328) is a potent inhibitor of sulfiredoxin (Srx) with IC50 of 6.7 uM.

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生物&药学活性

LMT328 (LMT-328) is a potent inhibitor of sulfiredoxin (Srx) with IC50 of 6.7 uM.
LMT328 effectively inhibits the growth of A549 human lung adenocarcinoma cells with IC50 of 12.13 uM.
LMT328 induces oxidative stress and apoptosis through reversible inhibition of Srx in A549 cells.
LMT328 induces oxidative mitochondrial damage.
LMT328 preferentially induces oxidative stress, mitochondrial damage, and cell death in cancer cells.
LMT328 (50 mg/kg, oral) suppresses tumor growth with low toxicity in A549 xenograft model

物理化学性质&存储条件

分子量	591.12
分子式	C31H31ClN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((4-(4-(2-chlorophenyl)piperazin-1-yl)-6-(2,4-dihydroxy-5-isopropylphenyl)pyrimidin-2-yl)thio)methyl)benzoic acid

参考文献

1. Lee GR, et al. Free Radic Biol Med. 2026 Apr 29;251:510-517.

LMT328 (LMT-328)

生物&药学活性

物理化学性质&存储条件

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LMT328 (LMT-328)

生物&药学活性

物理化学性质&存储条件

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