LMPTP inhibitor 23 |CAS:1908414-82-3 Probechem Biochemicals

Chemical Structure : LMPTP inhibitor 23

CAS No.: 1908414-82-3

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LMPTP inhibitor 23

货号: PC-60896Not For Human Use, Lab Use Only.

LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM.

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10 mg	￥2180	In stock
25 mg	￥3880	In stock
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生物&药学活性

LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM.
LMPTP inhibitor 23 displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B.
LMPTP inhibitor 23 inhibits uncompetitively LMPTP with Ki of 846 nM.
LMPTP inhibitor 23 substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss.

物理化学性质&存储条件

分子量	444.623
分子式	C28H36N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-diethyl-4-(4-((3-(piperidin-1-yl)propyl)amino)quinolin-2-yl)benzamide

参考文献

1. Stanford SM, et al. Nat Chem Biol. 2017 Jun;13(6):624-632.

LMPTP inhibitor 23

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LMPTP inhibitor 23

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