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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-LMP517
LMP517

Chemical Structure : LMP517

CAS No.: 1883730-99-1

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LMP517 (NSC 781517)

货号: PC-72441Not For Human Use, Lab Use Only.

LMP517 (NSC 781517) is a non-camptothecin, dual TOP1 and TOP2 topoisomerase inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LMP517 (NSC 781517) is a non-camptothecin, dual TOP1 and TOP2 topoisomerase inhibitor.
    LMP517 showed better antitumor activity than its parent compound LMP744 against H82 (small cell lung cancer) xenografts.

    物理化学性质&存储条件

    分子量 410.401
    分子式 C22H19FN2O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-fluoro-6-(3-((2-hydroxyethyl)amino)propyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione

    参考文献

    1. Laetitia Marzi, et al. Mol Cancer Ther. 2020 Aug;19(8):1589-1597.

    2. Marzi L, et al. Mol Cancer Ther. 2018 Aug;17(8):1694-1704.

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