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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-LMK-235
LMK-235

Chemical Structure : LMK-235

CAS No.: 1418033-25-6

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LMK-235 (LMK 235, LMK 235)

货号: PC-45595Not For Human Use, Lab Use Only.

LMK-235 (LMK235) is a selective HDAC5 and HDAC4 inhibitor with IC50 of 4.22 nM and 11.9 nM respectively.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LMK-235 (LMK235) is a selective HDAC5 and HDAC4 inhibitor with IC50 of 4.22 nM and 11.9 nM respectively.
LMK-235 is less potent for HDAC1/11/2/8.
LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 =0.49 and 0.32 uM respectively).

物理化学性质&存储条件

分子量 294.3462
分子式 C15H22N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-

参考文献

1. Marek L, et al. J Med Chem. 2013 Jan 24;56(2):427-36.

2. Li A, et al. Eur J Pain. 2013 Sep;17(8):1156-67.

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