LMI070 (NVS-SM1, Branaplam) | SMN2 splicing modulator

Chemical Structure : LMI070

CAS No.: 1562338-42-4

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货号: PC-45659Not For Human Use, Lab Use Only.

LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM), shows potential treatment of spinal muscular atrophy (SMA).

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LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM), shows potential treatment of spinal muscular atrophy (SMA).

分子量	393.4821
分子式	C22H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.12 mg/mL
Chemical Name/SMILES	Phenol, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-

1. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.

2. Palacino J, et al. Nat Chem Biol. 2015 Jul;11(7):511-7.