LMH001 | NOX2 inhibitor | Probechem Biochemicals

Chemical Structure : LMH001

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LMH001 (LMH 001)

货号: PC-38850Not For Human Use, Lab Use Only.

LMH001 is a small chemical compound blocking phosphorylated p47phox interaction with p22phox, inhibits effectively angiotensin II (AngII)-induced endothelial Nox2 activation and superoxide production (IC50=0.25 uM).

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生物&药学活性

LMH001 is a small chemical compound blocking phosphorylated p47phox interaction with p22phox, inhibits effectively angiotensin II (AngII)-induced endothelial Nox2 activation and superoxide production (IC50=0.25 uM).
LMH001 showed no effect on peripheral leucocyte oxidative response to pathogens.
LMH001 (2.5 mg/kg/d, ip. once) showed no effect on control mice, but inhibited completely AngII infusion-induced excess ROS production in vital organs, hypertension, aortic walls inflammation and reduced incidences of aortic aneurysm.

物理化学性质&存储条件

分子量	290.271
分子式	C15H14O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-dihydroxybenzyl 4-hydroxy-3-(hydroxymethyl)benzoate

参考文献

1. Lampson M Fan, et al. Redox Biol. 2022 May;51:102269. doi: 10.1016/j.redox.2022.102269.

LMH001 (LMH 001)

生物&药学活性

物理化学性质&存储条件

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LMH001 (LMH 001)

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物理化学性质&存储条件

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