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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-LMD-A
LMD-A

Chemical Structure : LMD-A

CAS No.: 850330-77-7

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LMD-A (CCR8 antagonist LMD-A)

货号: PC-60855Not For Human Use, Lab Use Only.

LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.
    LMD-A inhibits 10 nM CCL1-induced activation of CCR8 with EC50 of 12 nM.
    LMD-A inhibits 4DE4 cells cell migration induced by 3 nM CCL1 with EC50 of 0.58 nM.

    物理化学性质&存储条件

    分子量 508.637
    分子式 C27H32N4O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(N-((3R,4R)-1-(L-alanyl)-3-methylpiperidin-4-yl)sulfamoyl)naphthalen-1-yl)-2-methylbenzamide

    参考文献

    1. Rummel PC, et al. Br J Pharmacol. 2012 Nov;167(6):1206-17.

    2. Barington L, et al. J Biol Chem. 2016 Jul 29;291(31):16208-20.

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