LM-1685 | COX-2 inhibitor, LMO7 inhibitor | Probechem Biochemicals

Chemical Structure : LM-1685

CAS No.: 416901-58-1

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LM-1685 (LM1685)

货号: PC-26605Not For Human Use, Lab Use Only.

LM-1685 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 0.65 uM for COX-2 from human monocytes, with limited acitivty for COX-1.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

LM-1685 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 0.65 uM for COX-2 from human monocytes, with limited acitivty for COX-1.
Combination of Carboxyamido-triazole (CAI) and LM-1685 produces a cytotoxic effect by suppressing proliferation and triggering apoptosis in cancer cells.
LM-1685 also binds to LMO7 (LIM Domain 7) and inhibits OA progression.

物理化学性质&存储条件

分子量	377.84
分子式	C18H16ClNO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate

参考文献

1. Palomer A, et al. J Med Chem. 2002 Mar 28;45(7):1402-11.

2. Winters ME, et al. Cancer Res. 2005 May 1;65(9):3853-60.

3. Collins C, et al. J Cell Mol Med. 2009 Sep;13(9B):3236-50.

4. Zhang Q, et al. BMC Biol. 2026 Apr 16. doi: 10.1186/s12915-026-02587-7.

LM-1685 (LM1685)

生物&药学活性

物理化学性质&存储条件

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LM-1685 (LM1685)

生物&药学活性

物理化学性质&存储条件

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