LLY-507 |CAS:1793053-37-8 Probechem Biochemicals

Chemical Structure : LLY-507

CAS No.: 1793053-37-8

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LLY-507 (LLY507)

货号: PC-45598Not For Human Use, Lab Use Only.

LLY-507 is a potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM).

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

LLY-507 is a potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM).
LLY-507 displays >100-fold selective over a broad range of methyltransferase and non-methyltransferase targets.
LLY-507 inhibits SMYD2-mediated methylation of p53 Lys370 and suppresses proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner (IC50=1.5-6 uM).

物理化学性质&存储条件

分子量	574.7583
分子式	C36H42N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 15 mg/mL
Chemical Name/SMILES	[1,1'-Biphenyl]-3-carboxamide, 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-

参考文献

1. Nguyen H, et al. J Biol Chem. 2015 May 29;290(22):13641-53.

2. Olsen JB, et al. Mol Cell Proteomics. 2016 Mar;15(3):892-905.

LLY-507 (LLY507)

生物&药学活性

物理化学性质&存储条件

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LLY-507 (LLY507)

生物&药学活性

物理化学性质&存储条件

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