LLY-283 |CAS:2040291-27-6 Probechem Biochemicals

Chemical Structure : LLY-283

CAS No.: 2040291-27-6

加入收藏

LLY-283 (LLY283)

货号: PC-63461Not For Human Use, Lab Use Only.

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.
LLY-283 displays excellent against other arginine methyltransferases including the closely related PRMT7 and the type II PRMTs such as PRMT4 and 6.
LLY-283 decreases SmBB’-Rme2s levels in MCF7 cells with IC50 of 25 nM, also inhibits the PRMT5 mediated regulation of the splicing of MDM4.
LLY-283 inhibits proliferation of A375 cells with IC50 of 45.6 nM.
LLY-283 inhibits Tumor growth in mouse xenograft (A375, 20 mg/kg; QD).

物理化学性质&存储条件

分子量	342.36
分子式	C17H18N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol

参考文献

1. Zahid Q. Bonday, et al. ACS Med. Chem. Lett. 2018. DOI: 10.1021/acsmedchemlett.8b00014.

LLY-283 (LLY283)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LLY-283 (LLY283)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.