LLQ-45 | p53 Y220C agonist | Probechem Biochemicals

Chemical Structure : LLQ-45

加入收藏

LLQ-45 (LLQ45)

货号: PC-26507Not For Human Use, Lab Use Only.

LLQ-45 is a novel covalent agonist for p53 Y220C, restores the DNA-binding ability of p53 Y220C with EC50 of 24.97 uM, shows selective anti-proliferative activity against p53 Y220C.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LLQ-45 is a novel covalent agonist for p53 Y220C, restores the DNA-binding ability of p53 Y220C with EC50 of 24.97 uM, shows selective anti-proliferative activity against p53 Y220C.
LLQ-45 potently inhibits the proliferation of HUH-7 cells carrying the p53 Y220C mutation with IC50 of 1.35 uM, but not p53 WT-expressing cells.
LLQ-45 restores p53 transcriptional function at cellular level via key p53 target genes.
LLQ-45 forms covalent bond with Cys220 through Michael addition.

物理化学性质&存储条件

分子量	309.33
分子式	C16H15N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(1-cyclobutyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propane-1,2-dione

参考文献

1. Linquan Li, et al. Eur J Med Chem. 2026 Mar 31:311:118801.

LLQ-45 (LLQ45)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LLQ-45 (LLQ45)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.