LLP-3 | Survivin-Ran inhibitor | Probechem Biochemicals

Chemical Structure : LLP-3

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LLP-3 (Survivin-Ran inhibitor LLP-3)

货号: PC-21421Not For Human Use, Lab Use Only.

LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.

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生物&药学活性

LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.
LLP-3 does not affect the interaction of Survivin with other chromosomal passenger complex (CPC) proteins.
LLP-3 induces GBM cell apoptosis by inhibiting Survivin complex formation with Ran in a caspase- and p53 status–dependent manner.
LLP-3 inhibits Survivin interaction with Smac/DIABLO and small GTPase Ran.
LLP-3 induces apoptotic cell death in organotypic slice cultures of GBM surgical specimens.
LLP-3 abolishes the growth of patient-derived GBM spheres in vitro and in vivo.

物理化学性质&存储条件

分子量	535.00
分子式	C32H23ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,5-bis(benzyloxy)phenyl)-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

参考文献

1. Guvenc H, et al. Clin Cancer Res. 2013 Feb 1;19(3):631-42.

2. Galiger C, et al. BMC Cancer. 2023 Nov 25;23(1):1148.

LLP-3 (Survivin-Ran inhibitor LLP-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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LLP-3 (Survivin-Ran inhibitor LLP-3)

生物&药学活性

物理化学性质&存储条件

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