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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-LLL3
LLL3

Chemical Structure : LLL3

CAS No.: 63972-38-3

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LLL3 (STAT3 inhibitor LLL3)

货号: PC-61660Not For Human Use, Lab Use Only.

LLL3 is a structural analogue of STA-21 that acts as a novel STAT3 inhibitor, inhibits STAT3-dependent transcriptional and DNA binding activities.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LLL3 is a structural analogue of STA-21 that acts as a novel STAT3 inhibitor, inhibits STAT3-dependent transcriptional and DNA binding activities.
    LLL3 also inhibits viability of U87, U373, and U251 glioblastoma cells as well as induces apoptosis of these glioblastoma cell lines.
    LLL3 exhibits prolonged survival in U87 glioblastoma tumour-bearing mice.

    物理化学性质&存储条件

    分子量 266.252
    分子式 C16H10O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-acetyl-5-hydroxyanthracene-9,10-dione

    参考文献

    1. Fuh B, et al. Br J Cancer. 2009 Jan 13;100(1):106-12.

    2. Fossey SL, et al. BMC Cancer. 2009 Mar 10;9:81.

    3. Mencalha AL, et al. Cancer Chemother Pharmacol. 2010 May;65(6):1039-46.

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