LLL12B | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : LLL12B

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LLL12B (STAT3 inhibitor LLL12B)

货号: PC-47050Not For Human Use, Lab Use Only.

LLL12B is a selective STAT3 inhibitor that suppresses Th17 development, specifically inhibits STAT3 and suppresses Th17 differentiation and expansion.

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生物&药学活性

LLL12B is a selective STAT3 inhibitor that suppresses Th17 development, specifically inhibits STAT3 and suppresses Th17 differentiation and expansion.
LLL12B significantly suppressed STAT3 phosphorylation, IL-17 expression, and the proliferation of myelin-specific CD4+ T cells, significantly suppressed IL-6-induced IL-17 expression in CD4+ T cells, at both 0.125 μM and 0.25 μM.
LLL12B suppresses IL-23–induced expansion of Th17 cells from experimental autoimmune encephalomyelitis (EAE) mice, suppresses EAE progression in vivo.
LLL12B induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells.

物理化学性质&存储条件

分子量	374.367
分子式	C17H14N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9,10-dioxo-5-sulfamoyl-9,10-dihydroanthracen-1-yl dimethylcarbamate

参考文献

1. Aqel SI, et al. JCI Insight. 2021 Feb 22;6(4):e142376.

2. Chen X, et al. Sci Rep. 2021 Mar 22;11(1):6517.

LLL12B (STAT3 inhibitor LLL12B)

生物&药学活性

物理化学性质&存储条件

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LLL12B (STAT3 inhibitor LLL12B)

生物&药学活性

物理化学性质&存储条件

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