LLL12 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : LLL12

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LLL12 (STAT3 inhibitor LLL12)

货号: PC-60938Not For Human Use, Lab Use Only.

LLL12 is a nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer.

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10 mg		Get quote
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50 mg		Get quote

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生物&药学活性

LLL12 is a nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer.
LLL12 inhibit STAT3 phosphorylation (tyrosine 705) and induces apoptosis in various breast, pancreatic, and glioblastoma cancer cell lines with IC50 of 0.16-3.09 uM.
LLL12 also inhibits STAT3 phosphorylation induced by IL-6 and IFN-α in MM cells, but not STAT1, STAT2, STAT4 and STAT6 phosphorylation.
LLL12 inhibits STAT3 DNA binding activity and STAT3-dependent transcriptional activity, but not STAT1.
LLL12 exhibits potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model.

物理化学性质&存储条件

分子量	303.29
分子式	C14H9NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide

参考文献

1. Lin L, et al. Int J Cancer. 2012 Mar 15;130(6):1459-69.

2. Lin L, et al. Neoplasia. 2010 Jan;12(1):39-50.

3. Liu Y, et al. J Biol Chem. 2010 Aug 27;285(35):27429-39.

LLL12 (STAT3 inhibitor LLL12)

生物&药学活性

物理化学性质&存储条件

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LLL12 (STAT3 inhibitor LLL12)

生物&药学活性

物理化学性质&存储条件

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