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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-LL-K12-18
LL-K12-18

Chemical Structure : LL-K12-18

CAS No.: 3081311-94-3

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LL-K12-18

货号: PC-25971Not For Human Use, Lab Use Only.

LL-K12-18 is a potent, dual-site molecular glue degrader of cyclin K with DC50 of 0.38 nM in MDA-MB-231 cells, shows anti-proliferative effect against MDA-MB-231 cell with EC50 of 37 nM, enhances CDK12-DDB1 protein interaction.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LL-K12-18 is a potent, dual-site molecular glue degrader of cyclin K with DC50 of 0.38 nM in MDA-MB-231 cells, shows anti-proliferative effect against MDA-MB-231 cell with EC50 of 37 nM, enhances CDK12-DDB1 protein interaction.

物理化学性质&存储条件

分子量 559.50
分子式 C25H32Cl2N10O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(6-(((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-ethyl-9H-purin-2-yl)piperazin-1-yl)-2-(diethylamino)ethan-1-one

参考文献

1. Zhang Z, et al. Nat Commun. 2024 Aug 1;15(1):6477.

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