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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ribosomal S6 Kinase (RSK)-LJH-685
LJH-685

Chemical Structure : LJH-685

CAS No.: 1627710-50-2

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LJH-685 (LJH 685;LJH685)

货号: PC-45677Not For Human Use, Lab Use Only.

LJH-685 is a potent and specific pan-RSK inhibitor with IC50s of 6 nM,5 nM and 4 nM for RSK1,RSK2 and RSK3 respectively.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LJH-685 (LJH685) is a potent and specific pan-RSK inhibitor with IC50s of 6 nM,5 nM and 4 nM for RSK1, RSK2 and RSK3 respectively.
LJH-685 (LJH685) inhibts Y-box binding protein-1 (YB-1) Ser102 phosphorylation (EC50=0.2-0.3 uM) in MDA-MB-231 cancer cells.

物理化学性质&存储条件

分子量 381.4185
分子式 C22H21F2N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-

参考文献

1. Jain R, et al. J Med Chem. 2015 Sep 10;58(17):6766-83.

2. Aronchik I, et al. Mol Cancer Res. 2014 May;12(5):803-12.

3. Davies AH, et al. Oncotarget. 2015 Aug 21;6(24):20570-7.

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