LIMK-IN-14 |CAS:1116570-97-8 Probechem Biochemicals

Chemical Structure : LIMK-IN-14

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LIMK-IN-14

货号: PC-70098Not For Human Use, Lab Use Only.

LIMK-IN-14 is a potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively.

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生物&药学活性

LIMK-IN-14 is a potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively.
LIMK-IN-14 displays >100-fold selectivity for LIMK2 against ROCK1 and >900-fold selectivity against ROCK2.
LIMK-IN-14 reduces intraocular pressure to baseline levels in a steroid induced mouse model of ocular hypertension (topical dosing).

物理化学性质&存储条件

分子量	437.504
分子式	C22H27N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido)phenyl dimethylcarbamate

参考文献

1. Harrison BA, et al. J Med Chem. 2009 Nov 12;52(21):6515-8.

LIMK-IN-14

生物&药学活性

物理化学性质&存储条件

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LIMK-IN-14

生物&药学活性

物理化学性质&存储条件

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