LIH383 | ACKR3 agonist | Probechem Biochemicals

Chemical Structure : LIH383

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LIH383 (LIH-383, FGGFMRRK-NH2)

货号: PC-22933Not For Human Use, Lab Use Only.

LIH383 is a potent, selective atypical chemokine receptor ACKR3 (CXCR7) agonist with EC50 of 0.61 nM in inducing β-arrestin recruitment to ACKR3.

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生物&药学活性

LIH383 is a potent, selective atypical chemokine receptor ACKR3 (CXCR7) agonist with EC50 of 0.61 nM in inducing β-arrestin recruitment to ACKR3.
LIH383 competed directly with CXCL12-AF647 for ACKR3 binding at low nanomolar concentrations.
LIH383 shows equivalent activity on human and mouse ACKR3 (mACKR3).
LIH383 is more potent in inducing β-arrestin recruitment to ACKR3 than the full-length chemokine ligands CXCL12 or CXCL11 (EC50 =1.2 nM and 2.2 nM, respectively).

物理化学性质&存储条件

分子量	997.24
分子式	C45H72N16O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2

参考文献

1. Max Meyrath, et al. Nat Commun. 2020 Jun 19;11(1):3033.

LIH383 (LIH-383, FGGFMRRK-NH2)

生物&药学活性

物理化学性质&存储条件

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LIH383 (LIH-383, FGGFMRRK-NH2)

生物&药学活性

物理化学性质&存储条件

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