LIBX-A401

Chemical Structure : LIBX-A401

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货号: PC-24108Not For Human Use, Lab Use Only.

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50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

LIBX-A401 is a potent, selective inhibitor of Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) with IC50 of 0.38 uM, MST KD of 0.72 uM, with high selectivity over ACSL3 (IC50>50 uM), protects cells from ferroptosis.
LIBX-A401 is derived from rosiglitazone but devoid of PPARγ activity
LIBX-A401 stabilizes the ACSL4 C-terminus, and altersthe fatty acid (FA) gate domain.
LIBX-A401 exhibits significant anti-ferroptotic properties in cells.
LIBX-A401 (2.5 µM) significantly prevented RSL3-induced cell death in bothHEK293 and HT-1080 cells.
LIBX-A401 (2.5 µM) effectively inhibited cell death caused by AA+Fe treatment in LUHMES cells.

物理化学性质&存储条件

分子量	339.39
分子式	C20H21NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (E)-3-(4-(2-(N-methylbenzamido)ethoxy)phenyl)acrylate

参考文献

1. Mazhari Dorooee D, et al. Angew Chem Int Ed Engl. 2025 Feb 28:e202500518.

LIBX-A401

生物&药学活性

物理化学性质&存储条件

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LIBX-A401

生物&药学活性

物理化学性质&存储条件

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