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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Arenavirus-LHF-535
LHF-535

Chemical Structure : LHF-535

CAS No.: 1450929-77-7

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LHF-535 (LHF535, LHF 535)

货号: PC-35909Not For Human Use, Lab Use Only.

LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM.

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10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM。
LHF-535 has sub-nanomolar potency against the viral envelope glycoproteins from all Lassa virus lineages, with the exception of the glycoprotein from the LP strain from lineage I, which was 100-fold less sensitive than that of other strains.
LHF-535 potently inhibited Junín virus, but not Candid#1 in virus-yield reduction assays.
LHF-535 protects mice in a lethal Tacaribe virus model at 10 mg/kg.

物理化学性质&存储条件

分子量 412.533
分子式 C27H28N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-2-(4-(2-(1-(4-isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol

参考文献

1. Madu IG, et al. PLoS Pathog. 2018 Dec 21;14(12):e1007439.

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