LH1513 | CaOx crystallization inhibitor | Probechem Biochemicals

Chemical Structure : LH1513

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LH1513 (L-Lysine Dioxalate)

货号: PC-23544Not For Human Use, Lab Use Only.

LH1513 (L-Lysine Dioxalate) is potent inhibitor of calcium oxalate (CaOx) crystallization with EC50 of 21.7 uM.

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生物&药学活性

LH1513 (L-Lysine Dioxalate) is potent inhibitor of calcium oxalate (CaOx) crystallization with EC50 of 21.7 uM.
LH1513 (L-Lysine Dioxalate) is more potent than citrate and pyruvate.
LH1513 (L-Lysine Dioxalate) ahs sufficient oral bioavailability for a preliminary in vivo study demonstrating efficacy in preventing urinary CaOx crystal formation in an Agxt-knockout mouse model for hyperoxaluria.

物理化学性质&存储条件

分子量	356.17
分子式	C10H11N2Na3O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (S)-2,2'-((1-carboxylatopentane-1,5-diyl)bis(azanediyl))bis(2-oxoacetate)

参考文献

1. Longqin Hu, et al. ACS Med Chem Lett. 2024 Nov 4;15(11):2005-2011.

LH1513 (L-Lysine Dioxalate)

生物&药学活性

物理化学性质&存储条件

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LH1513 (L-Lysine Dioxalate)

生物&药学活性

物理化学性质&存储条件

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