欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-LGR6768
LGR6768

Chemical Structure : LGR6768

CAS No.:

加入收藏

LGR6768 (LGR 6768)

货号: PC-20315Not For Human Use, Lab Use Only.

LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs.
    LGR6768 shows higher selectivity index than LDC4297 and samuraciclib.
    LGR6768 shows antiproliferative and proapoptotic effect against a panel of 10 cell lines derived from haematological malignancies (IC50=0.4-4 uM).
    LGR6768 downregulates the expression of transcription factors and apoptosis-related genes in the SEM and MOLM-13 cell lines.

    物理化学性质&存储条件

    分子量 458.63
    分子式 C26H30N6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-([1,1'-biphenyl]-2-ylmethyl)-3-isopropyl-5-(piperidin-4-ylthio)-2H-pyrazolo[4,3-d]pyrimidin-7-amine

    参考文献

    1. Kovalová M, et al. Biomed Pharmacother. 2023 Mar 15;161:114492.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: