WNT-974 | Porcupine inhibitor | Probechem Biochemicals

Chemical Structure : LGK974

CAS No.: 1243244-14-5

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LGK974 (LGK-974, WNT 974, WNT974 )

货号: PC-45342Not For Human Use, Lab Use Only.

LGK974 (WNT974) is a potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

LGK974 (WNT974) is a potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.
WNT974 potently inhibits Wnt signaling with IC50 of 0.4 nM, with no major cytotoxicity.
WNT974 reduces Wnt-dependent LRP6 phosphorylation and the expression of Wnt target genes, such as AXIN2.
WNT974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo.

物理化学性质&存储条件

分子量	396.4445
分子式	C23H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-

参考文献

1. Liu J, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9.

2. Jiang X, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54.

3. Moon J, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654.

LGK974 (LGK-974, WNT 974, WNT974 )

生物&药学活性

物理化学性质&存储条件

参考文献

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LGK974 (LGK-974, WNT 974, WNT974 )

生物&药学活性

物理化学性质&存储条件

参考文献

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