LGD-6972 (RVT 1502) | GCGR antagonist | Probechem Biochemicals

Chemical Structure : LGD-6972

CAS No.: 1207989-09-0

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LGD-6972 (LGD6972, RVT1502)

货号: PC-43093Not For Human Use, Lab Use Only.

LGD-6972 (RVT 1502) is a novel potent, selective, orally bioavailable glucagon receptor (GCGR) antagonist.

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5 mg	￥2280	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
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LGD-6972 (RVT 1502) is a novel potent, selective, orally bioavailable glucagon receptor (GCGR) antagonist; binds competitively to GCGR with high affinity and selectivity, suppressing both cAMP and glucose production in vitro.
LGD-6972 reduces acute glucagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models in vivo.

物理化学性质&存储条件

分子量	702.9008
分子式	C43H46N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Ethanesulfonic acid, 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]benzoyl]amino]-

参考文献

1. Vajda EG, et al. Diabetes Obes Metab. 2017 Jan;19(1):24-32.

2. Vajda EG, et al. Diabetes. 2012;61(suppl 1):A252. Abstract.

LGD-6972 (LGD6972, RVT1502)

生物&药学活性

物理化学性质&存储条件

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LGD-6972 (LGD6972, RVT1502)

生物&药学活性

物理化学性质&存储条件

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