LGB-321 |Cas:1210416-93-5 Buy LGB-321 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : LGB-321

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LGB-321 (LGB 321;LGB321)

货号: PC-70113Not For Human Use, Lab Use Only.

LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.
LGB-321 inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in PIM2-dependent MM cell lines.
LGB-321 shows activity in cell lines derived from diverse hematological lineages, including ALL, AML, NHL.
LGB-321 shows activity in the KG-1 AML xenograft model, and synergizes with cytarabine.

物理化学性质&存储条件

分子量	530.37
分子式	C23H24Cl2F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide hydrochloride

参考文献

1. Garcia PD, et al. Clin Cancer Res. 2014 Apr 1;20(7):1834-45.

LGB-321 (LGB 321;LGB321)

生物&药学活性

物理化学性质&存储条件

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LGB-321 (LGB 321;LGB321)

生物&药学活性

物理化学性质&存储条件

参考文献

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