LG100268 | RXR agonist | Probechem Biochemicals

Chemical Structure : LG100268

CAS No.: 153559-76-3

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LG100268 (LG268)

货号: PC-23687Not For Human Use, Lab Use Only.

LG100268 (LG268) is a potent, selective, orally active retinoid X receptor (RXR) agonist with EC50 of 4 nM, 3 nM, and 4 nM for RXRα, RXRβ, and RXRγ, respectively.

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10 mg	￥1380	In stock
25 mg	￥2380	In stock
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100 mg		Get quote

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生物&药学活性

LG100268 (LG268) is a potent, selective, orally active retinoid X receptor (RXR) agonist with EC50 of 4 nM, 3 nM, and 4 nM for RXRα, RXRβ, and RXRγ, respectively.
LG100268 displays >1000-fold selectivity for RXR over RAR, and has Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXRα, RXRβ, and RXRγ, respectively.
LG100268 activates RXR homodimers to induce transcriptional activation.
LG100268 shows anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.

物理化学性质&存储条件

分子量	363.50
分子式	C24H29NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid

参考文献

1. Bissonnette RP, et al. Mol Cell Biol. 1995 Oct;15(10):5576-85.

2. Boehm MF, et al. J Med Chem. 1995 Aug 4;38(16):3146-55.

3. Allegretto EA, et al. J Biol Chem. 1995 Oct 13;270(41):23906-9.

LG100268 (LG268)

生物&药学活性

物理化学性质&存储条件

参考文献

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LG100268 (LG268)

生物&药学活性

物理化学性质&存储条件

参考文献

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