LFHP-1c

Chemical Structure : LFHP-1c

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货号: PC-23800Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

LFHP-1c is a direct phosphoglycerate mutase family member 5 (PGAM5) inhibitor with binding SPR KD of 961 nM, not only inhibits the PGAM5 phosphatase activity, but also reduces the interaction of PGAM5 with NRF2.
LFHP-1c dose-dependently protects rat brains against ischemia/reperfusion injury.
LFHP-1c prevents BBB disruption and attenuates endothelial inflammation in rat cerebral microvessels.
LFHP-1c prevents brain microvascular endothelial cells injury under OGD/R condition.
LFHP-1c targets PGAM5 to facilitate nuclear translocation of NRF2 for endothelial protection in stroke.
LFHP-1c ameliorates brain ischemic injury in tMCAO model of M. fascicularis through PGAM5–NRF2 axis.

物理化学性质&存储条件

分子量	873.16
分子式	C55H64N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-((8-(4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxamido)octyl)carbamoyl)phenyl)pentyl acetate

参考文献

1. Gao C, et al. Acta Pharm Sin B. 2021 Jul;11(7):1867-1884.

LFHP-1c

生物&药学活性

物理化学性质&存储条件

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LFHP-1c

生物&药学活性

物理化学性质&存储条件

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