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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Diacylglycerol Lipase (DAGL)-LEI-106
LEI-106

Chemical Structure : LEI-106

CAS No.: 1620582-23-1

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LEI-106 (LEI 106)

货号: PC-20127Not For Human Use, Lab Use Only.

LEI-106 (LEI 106) is a potent, dual DAGL-α/ABHD6 inhibitor with Ki values of 0.7/0.8 uM, respectively.

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5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LEI-106 (LEI 106) is a potent, dual DAGL-α/ABHD6 inhibitor with Ki values of 0.7/0.8 uM, respectively.
LEI-106 is a sulfonamide derivative in the biochemical assay with an IC50 of 18 nM for DAGL-α and inhibited the hydrolysis of [14C]-sn-1-oleoyl-2-arachidonoyl-glycerol, the natural substrate of DAGL-α with Ki of 0.7 uM.

物理化学性质&存储条件

分子量 481.56
分子式 C26H27NO6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((2,2-dimethylchroman-6-yl)sulfonyl)-N-(4-phenoxybenzyl)glycine

参考文献

1. Freek J Janssen, et al. J Med Chem. 2014 Aug 14;57(15):6610-22.

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