LEI-101 | CB2R agonist | Probechem Biochemicals

Chemical Structure : LEI-101

加入收藏

LEI-101 (LEI 101)

货号: PC-20747Not For Human Use, Lab Use Only.

LEI-101 (LEI 101) is a potent, selective, orally available and peripherally restricted cannabinoid CB2 receptor agonist with binding pKi of 7.5 (hCB2R).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LEI-101 (LEI 101) is a potent, selective, orally available and peripherally restricted cannabinoid CB2 receptor agonist with binding pKi of 7.5 (hCB2R).
LEI-101 displays 100‐fold selectivity for CB2 receptors over CB1 receptors in binding assays, does not interact with other proteins of the endocannabinoid system: human FAAH (hFAAH), MAGL, NAPE‐PLD and DAGL.
LEI‐101 behaves as a CB2 receptor partial agonist in the β‐arrestin recruitment and GTPγS assays with pEC50 of 8.0 and 7.0, respectively.
LEI‐101 (60 mg/kg, p.o.) does not induce cannabimimetic effects in vivo.
LEI‐101 (3.0 or 10 mg/kg, p.o. and i.p.) attenuates biomarkers and histological damage of cisplatin‐induced nephropathy in C57Bl6/J mice, prevents cisplatin‐induced increases in serum creatinine and BUN levels.
LEI‐101 attenuates cisplatin‐induced renal 3‐nitrotyrosine (3‐NT) formation, attenuates cisplatin (Cis)‐induced renal HNE adducts formation in wild type, but not in CB2R‐/‐ mice.

物理化学性质&存储条件

分子量	472.54
分子式	C23H25FN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1N(C2CC2)C(CN1CC3=CC=C(C4=NC(CN(CC5)CCS5(=O)=O)=C(F)C=C4)C=C3)=O

参考文献

1. Mukhopadhyay P, et al. Br J Pharmacol. 2016 Feb;173(3):446-58.

LEI-101 (LEI 101)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LEI-101 (LEI 101)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.