LE-540 |CAS:188645-44-5 Probechem Biochemicals

Chemical Structure : LE-540

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LE-540 (LE 540;LE540)

货号: PC-70292Not For Human Use, Lab Use Only.

LE-540 (LE540) is a potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements.

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生物&药学活性

LE-540 (LE540) is a potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements.
LE-540 inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells.
LE-540 strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.

物理化学性质&存储条件

分子量	488.631
分子式	C33H32N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(10,10,13,13,15-pentamethyl-11,12,13,15-tetrahydro-10H-dinaphtho[2,3-b:1',2'-e][1,4]diazepin-7-yl)benzoic acid

参考文献

1. Li Y, et al. J Biol Chem. 1999 May 28;274(22):15360-6.

2. Kitaoka K, et al. Brain Res. 2011 Nov 14;1423:10-6.

3. Umemiya H, et al. J Med Chem. 1997 Dec 19;40(26):4222-34.

LE-540 (LE 540;LE540)

生物&药学活性

物理化学性质&存储条件

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LE-540 (LE 540;LE540)

生物&药学活性

物理化学性质&存储条件

参考文献

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