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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Anaplastic Lymphoma Kinase (ALK)-LDN193189
LDN193189

Chemical Structure : LDN193189

CAS No.: 1062368-24-4

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LDN193189 (LDN 193189;LDN-193189;DM-3189;DM 3189)

货号: PC-42884Not For Human Use, Lab Use Only.

LDN193189 (DM 3189) is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM).

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10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LDN193189 (DM 3189) is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM).
LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7.
LDN193189 also blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins.
LDN193189 affects BMP-induced osteoblast differentiation, attenuates ectopic ossification in vivo.

物理化学性质&存储条件

分子量 406.4824
分子式 C25H22N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

Ethanol: 0.25 mg/mL (Need ultrasonic and warming); DMSO: < 0.1 mg/mL; H2O: < 0.1 mg/mL
Chemical Name/SMILES

Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-

参考文献

1. Yu PB, et al. Nat Med. 2008 Dec;14(12):1363-9.

2. Cuny GD, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4388-92.

3. Cannon JE, et al. Br J Pharmacol. 2010 Sep;161(1):140-9.

4. Steinbicker AU, et al. Blood. 2011 May 5;117(18):4915-23.

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