欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Haspin Kinase-LDN192960
LDN192960

Chemical Structure : LDN192960

CAS No.: 184582-62-5

加入收藏

LDN192960 (LDN-192960, LDN 192960)

货号: PC-21469Not For Human Use, Lab Use Only.

LDN192960 (LDN 192960) is a highly potent and selective, dual Haspin and DYRK2 inhibitor with IC50 of 10 nM and 48 nM respectively.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LDN192960 (LDN 192960) is a highly potent and selective, dual Haspin and DYRK2 inhibitor with IC50 of 10 nM and 48 nM respectively.
LDN192960 suppresses Thr25 RPT3 phosphorylation in a dose-dependent manner in HEK293T cells transiently overexpressing DYRK2-FLAG, with maximal effects at 1-10 uM.
LDN192960 does not inhibit any of the 130+ kinases including other CMGC kinase family members that are closely related to the DYRKs.
LDN192960 binds to the ATP-binding pocket of DYRK2, also potently inhibits DYRK1A, DYRK3 and Pim with IC50 of <3, 122 and 10 nM, respectively.
LDN192960 perturbs proteasome activity, induces cell death, and impedes proliferation and invasion on MDA-MB-468 cells.
LDN192960 impedes MM progression and delays myeloma-mediated bone degeneration.
LDN192960 induces cytotoxicity in bortezomib-resistant MM, both in cells and in vivo. significantly alleviates tumor burden in standard and PDX TNBC models.

物理化学性质&存储条件

分子量 328.43
分子式 C18H20N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2,7-dimethoxyacridin-9-yl)thio)propan-1-amine

参考文献

1. Banerjee S, et al. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24881-24891.
2. Cuny GD, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: