欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-LDN-212854
LDN-212854

Chemical Structure : LDN-212854

CAS No.: 1432597-26-6

加入收藏

LDN-212854 (LDN212854)

货号: PC-21393Not For Human Use, Lab Use Only.

LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM).

规格 价格 库存 数量
10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM).
LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.
LDN-212854 suppresses HCC tumor progression through repression of ID1 in HCC xenografts model.

物理化学性质&存储条件

分子量 406.49
分子式 C25H22N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

参考文献

1. Mohedas AH, et al. ACS Chem Biol. 2013;8(6):1291-302.

2. Han Chen, et al. Mol Oncol. 2021 Aug;15(8):2203-2218.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: