LDD1937 |CAS: 2319608-75-6 Probechem Biochemicals

Chemical Structure : LDD1937

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LDD1937 (LDD 1937;LDD-1937)

货号: PC-63548Not For Human Use, Lab Use Only.

LDD1937 is a selective, potent FLT3 inhibitor with IC50 of 3 nM, displays >170-fold selectivity over JAK2/3, c-MET, IRAK-4.

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生物&药学活性

LDD1937 is a selective, potent FLT3 inhibitor with IC50 of 3 nM, displays >170-fold selectivity over JAK2/3, c-MET, IRAK-4.
LDD1937 selectively inhibits the growth of MV-4-11 cells (GI50=1 nM) and induces apoptotic cell death, causes cell cycle arrest at the G2/M phase and increases the cell population at the sub-G1 phase.
LDD1937 significantly reduces phosphorylation of STAT5, demonstrates in vivo anti-tumor effect in MV-4-11 xenograft models.

物理化学性质&存储条件

分子量	520.411
分子式	C24H27Cl2N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (2Z,3E)-2'-oxo-3-((2-(piperazin-1-yl)ethoxy)imino)-[2,3'-biindolinylidene]-5'-carboxylate dihydrochloride

参考文献

1. Lee HJ, et al. Oncotarget. 2017 Dec 14;9(1):924-936.

LDD1937 (LDD 1937;LDD-1937)

生物&药学活性

物理化学性质&存储条件

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LDD1937 (LDD 1937;LDD-1937)

生物&药学活性

物理化学性质&存储条件

参考文献

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