LDC8201 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : LDC8201

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LDC8201 (LDC-8201)

货号: PC-38640Not For Human Use, Lab Use Only.

LDC8201 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.

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生物&药学活性

LDC8201 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.
LDC8201 demonstrated tumor shrinkage in mice engrafted with patient-derived EGFR-H773_V774insNPH mutant cells

物理化学性质&存储条件

分子量	486.016
分子式	C28H28ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(4-chloro-2-(4-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methylphenyl)acrylamide

参考文献

1. Jonas Lategahn, et al. J Med Chem. 2022 Apr 29. doi: 10.1021/acs.jmedchem.1c02080.

LDC8201 (LDC-8201)

生物&药学活性

物理化学性质&存储条件

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LDC8201 (LDC-8201)

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物理化学性质&存储条件

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