LDC0496 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : LDC0496

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LDC0496 (LDC-0496)

货号: PC-38641Not For Human Use, Lab Use Only.

LDC0496 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.

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100 mg		Get quote

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生物&药学活性

LDC0496 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.

物理化学性质&存储条件

分子量	537.664
分子式	C32H35N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	isopropyl 3-(3-acrylamido-4-methylphenyl)-2-(4-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

参考文献

1. Jonas Lategahn, et al. J Med Chem. 2022 Apr 29. doi: 10.1021/acs.jmedchem.1c02080.

LDC0496 (LDC-0496)

生物&药学活性

物理化学性质&存储条件

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LDC0496 (LDC-0496)

生物&药学活性

物理化学性质&存储条件

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