LCS3 | GSR inhibitor | Probechem Biochemicals

Chemical Structure : LCS3

CAS No.: 109844-92-0

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LCS3 (GSR inhibitor LCS3)

货号: PC-72885Not For Human Use, Lab Use Only.

LCS3 is a small molecule that selectively impairs the growth of human lung adenocarcinoma (LUAD) cells, induces oxidative stress, inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively.

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10 mg	￥1980	In stock
25 mg	￥3280	In stock
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生物&药学活性

LCS3 is a small molecule that selectively impairs the growth of human lung adenocarcinoma (LUAD) cells, induces oxidative stress, inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively.
LCS3 selectively inhibited the growth of 24/25 NSCLC cell lines at low micromolar concentrations (CI50<5 uM), but not the non-transformed lung cell lines (IC50>10 uM).
LCS3 induces ROS and NRF2 pathway activation in sensitive LUAD cells.
LCS3 inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively, inhibits GSR through a reversible, uncompetitive mechanism.
LCS3 induces synergistic inhibition of the glutathione and thioredoxin pathways.

物理化学性质&存储条件

分子量	266.637
分子式	C11H7ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide

参考文献

1. Fraser D Johnson, et al. Cell Rep. 2022 Feb 8;38(6):110343.

LCS3 (GSR inhibitor LCS3)

生物&药学活性

物理化学性质&存储条件

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LCS3 (GSR inhibitor LCS3)

生物&药学活性

物理化学性质&存储条件

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