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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Src-LCL204
LCL204

Chemical Structure : LCL204

CAS No.: 366487-89-0

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LCL204 (LCL 204, LCL-204)

货号: PC-61226Not For Human Use, Lab Use Only.

LCL204 is a small molecule that inhibits N-myristoyltransferase (NMT1) with IC50 of 8.7 uM, 10-fold enhanced inhibitory potency than LCL4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LCL204 is a small molecule that inhibits N-myristoyltransferase (NMT1) with IC50 of 8.7 uM, 10-fold enhanced inhibitory potency than LCL4.
    LCL204 blocks Src myristoylation and Src localization to the cytoplasmic membrane.
    LCL204 attenuates Src-mediated oncogenic signaling, suppresses cell-cycle progression, proliferation, and malignant growth of prostate cancer cells.

    物理化学性质&存储条件

    分子量 408.583
    分子式 C23H40N2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R)-1-(4-nitrophenyl)-2-(tetradecylamino)propane-1,3-diol

    参考文献

    1. Kim S, et al. Cancer Res. 2017 Dec 15;77(24):6950-6962.

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