LCC03 | Autophagy inducer | Probechem Biochemicals

Chemical Structure : LCC03

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LCC03 (LCC 03)

货号: PC-73072Not For Human Use, Lab Use Only.

LCC03 is a salicylanilide derivative and autophagy inducer, dose-dependently suppresses proliferation and retarded cell-cycle progression in CRPC cells (IC50, 0.69 to 4.8 uM).

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生物&药学活性

LCC03 is a salicylanilide derivative and autophagy inducer, dose-dependently suppresses proliferation and retarded cell-cycle progression in CRPC cells (IC50, 0.69 to 4.8 uM).
The classical autophagy features, including autophagosome formation and LC3-II conversion, were dramatically shown in LCC03-treated CRPC cells, which was associated with the suppressed AKT/mTOR signaling pathways, a major negative regulator of autophagy.
LCC03 also showed an expanded morphology of the endoplasmic reticulum (ER), increased expression of the ER stress markers GRP78 and PERK, and eIF2α phosphorylation.
The PERK-eIF2α pathway contributed to the LCC03-induced autophagy.
LCC03 suppressed the growth of CRPC xenografts in mouse bone without systemic toxicity in tumor-bearing mice.

物理化学性质&存储条件

分子量	361.296
分子式	C19H11F4NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy[1,1'-biphenyl]-3-carboxamide

参考文献

1. Hsieh CL, et al. Mol Cancer Ther. 2020 Jan;19(1):101-111.

LCC03 (LCC 03)

生物&药学活性

物理化学性质&存储条件

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LCC03 (LCC 03)

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