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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Discoidin Domain Receptor (DDR)-LCB 03-0110
LCB 03-0110

Chemical Structure : LCB 03-0110

CAS No.: 1228102-01-9

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LCB 03-0110 (LCB03-0110)

货号: PC-63519Not For Human Use, Lab Use Only.

LCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family, as well as Btk and Syk.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family, as well as Btk and Syk.
    LCB 03-0110 potently inhibits the activated tyrosine kinase activity of DDR2 (IC50=6 nM), and nonactivated form of DDR2 (IC50=145 nM).
    LCB 03-0110 suppresses collagen-induced autophosphorylation of DDR1 and DDR2 with IC50 of 164 and 171 nM in cell-based assays.
    LCB 03-0110 inhibits all eight Src family kinases with IC50 of 2-20 nM.
    LCB 03-0110 suppresses the proliferation and migration of primary dermal fibroblasts induced by TGF β1 and type I collagen (IC50=194 nM), inhibits cell migration and nitric oxide, iNOS, COX2, and TNF-α synthesis in LPS-activated J774A.1 macrophage cells.
    LCB 03-0110 suppresses hypertrophic scar formation in wound healing models.

    物理化学性质&存储条件

    分子量 417.527
    分子式 C24H23N3O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol

    参考文献

    1. Sun X, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9.

    2. Jung SH, et al. Br J Dermatol. 2013 Jan;168(1):112-9.

    3. Kim BH, et al. Exp Dermatol. 2015 Jul;24(7):503-9.

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